The Argentina international scored twice early on against Maurizio Sarri's men to write yet another chapter in the history books
Ivory Coast and Chelsea great Didier Drogba announced his retirement on Wednesday after a 20-year career.
With the Premier League's transfer window closing on Thursday, the top title contenders have completed their squad building until January.
Here we look at how the division's elite teams fared in the transfer market and what their prospects are for the coming season:
Romelu Lukaku broke his barren run against top six Premier League opposition and provided the winner for Jesse Lingard as Manchester United came from behind to beat Chelsea 2-1 at Old Trafford.
Antonio Conte said Chelsea's hopes of defending their Premier League title are gone following a surprise 1-0 defeat by struggling West Ham on Saturday.
The 48-year-old Italian told Sky Sports that Chelsea's fourth defeat of the campaign had dealt a killer blow to their chances.
Liverpool forwards Roberto Firmino, Sadio Mane and Mohamed Salah tore Arsenal to shreds as Arsene Wenger's team crashed to a humiliating 4-0 defeat at Anfield on Sunday.
Premier League defending champion, Chelsea did not get the kind of start they would have wished for as the Antonio Conte side were stunned at home 3-2 by visiting Burnley last Saturday.